Protein basic information
| LiverAtlas Protein ID |
HuLPr47857 |
|
Uniprot ID |
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Uniprot Acc |
Q9NUQ3;Q2KQ75;Q5JNZ7;Q9P0X1; |
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Protein name |
Gamma-taxilin |
|
Comment |
FUNCTION:May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.||SUBUNIT:Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.||SUBCELLULAR LOCATION:Nucleus membrane. Cytoplasm, cytosol (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NUQ3-1; Sequence=Displayed; Name=2; IsoId=Q9NUQ3-2; Sequence=VSP 039391;||TISSUE SPECIFICITY:Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.||INDUCTION:By bacterial lipopolysaccharides (LPS) in HepG2 cells.||MISCELLANEOUS:Depletion of TXLNG by siRNA decreases the percentage of HepG2 cells a |
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Subcellular localization |
Nucleus membrane.Cytoplasm, cytosol(By similarity). |
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Gene name |
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Protein sequence
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MATRVEEAARGRGGGAEEATEAGRGGRRRSPRQKFEIGTM EEAGICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHS LEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDP PDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLA ALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQS EHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEE RRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGE KLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQ LIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQ QLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKK LEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIK LERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAAN RDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQ RSAVQKPPSTGSAPAIESVD |
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Database cross reference |
RefSeq Protein accession:NP_001162154
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IEA:UniProtKB-SubCell. GO:0031965;C:nuclear membrane;IEA:UniProtKB-SubCell. |
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GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47857 |
PHOSPHORYLATION |
102 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
105 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
517 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
520 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
97 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
283 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
371 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
105 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
102 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
86 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
97 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47857 |
PHOSPHORYLATION |
30 |
S |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
Validated_transcriptional_targets_of_AP1_family_members_Fra1_and_Fra2 |
