Protein basic information
| LiverAtlas Protein ID |
HuLPr47874 |
|
Uniprot ID |
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|
Uniprot Acc |
O95551;B4DKL8;B4DQ95;Q2TBE2;Q5JYM0;Q7Z6U5;Q9NUK5;Q9NYY9; |
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Protein name |
Tyrosyl-DNA phosphodiesterase 2 |
|
Comment |
FUNCTION:DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.||COFACTOR:Magnesium (Probable).||SUBUNIT:Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR |
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Subcellular localization |
Nucleus.Nucleus, PML body. |
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Gene name |
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Protein sequence
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MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDA AVAQCFLAENDWEMERALNSYFEPPVEESALERRPETIS EPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLIT WNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPY YSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEI IPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAA ERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCG GLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKL RFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHW GLLCNLDIIL |
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Database cross reference |
RefSeq Protein accession:NP_057698
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0016605;C:PML body;IDA:UniProtKB. |
|
GO-F |
GO:0070260;F:5'-tyrosyl-DNA phosphodiesterase activity;IDA:UniProtKB. GO:0000287;F:magnesium ion binding;TAS:UniProtKB. GO:0004518;F:nuclease activity;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0003714;F:transcription corepressor |
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GO-P |
GO:0007166;P:cell surface receptor linked signaling pathway;TAS:ProtInc. GO:0006302;P:double-strand break repair;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47874 |
PHOSPHORYLATION |
139 |
Y |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr47874 |
PHOSPHORYLATION |
157 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47874 |
PHOSPHORYLATION |
158 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47874 |
PHOSPHORYLATION |
160 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47874 |
PHOSPHORYLATION |
88 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47874 |
PHOSPHORYLATION |
92 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47874 |
PHOSPHORYLATION |
61 |
Y |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name | |
| Pathway name |
