HuLPr47892

Uniprot ID

U17L1_HUMAN

Uniprot Acc

Q7RTZ2;

Protein name

Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 1

Comment

FUNCTION:Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates (By similarity).||CATALYTIC ACTIVITY:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).||SUBCELLULAR LOCATION:Nucleus, nucleolus (By similarity).||SIMILARITY:Belongs to the peptidase C19 family. USP17 subfamily.||CAUTION:Could be the product of a pseudogene.||CAUTION:The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found both on chromosome 4 and chromosome 8.

Subcellular localization

Nucleus, nucleolus(By similarity).

Gene name

ubiquitin specific peptidase 17-like 1, pseudogene

Protein sequence

MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEK SPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVG AGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQ RPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGK QEDVHEFLMFTVDAMKKACLPGHKQVDHHCKDTTLIHQI FGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQ ALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAK VLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTG PLVYVLYAVLVHAGWSCHDGHYFSYVKAQEVQWYKMDDA EVTVCSIISVLSQQAYVLFYIQKSEWERHSESVSRGREP RALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQ ESTLDHWKFLQEQNKTKPEFNVGKVEGTLPPNALVIHQS KYKCGMKNHHPEQQSSLLNLSSTTRTDQESMNTGTLASL QGRTRRAKGKNKHSKRALLVCQ

Database cross reference

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005730;C:nucleolus;IEA:UniProtKB-SubCell.

GO-F

GO:0008234;F:cysteine-type peptidase activity;IEA:UniProtKB-KW. GO:0004221;F:ubiquitin thiolesterase activity;IEA:InterPro.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0006511;P:ubiquitin-dependent protein catabolic process;IEA:InterPro.