HuLPr47933

Uniprot ID

UBA7_HUMAN

Uniprot Acc

P41226;Q9BRB2;

Protein name

Ubiquitin-like modifier-activating enzyme 7

Comment

FUNCTION:Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.||TISSUE SPECIFICITY:Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.||MISCELLANEOUS:There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.||SIMILARITY:Belongs to the ubiquitin-activating E1 family.

Gene name

ubiquitin-like modifier activating enzyme 7

Protein sequence

MDALDASKLLDEELYSRQLYVLGSPAMQRIQGARVLVSGL QGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLS EQDLERSRAEASQELLAQLNRAVQVVVHTGDITEDLLLD FQVVVLTAAKLEEQLKVGTLCHKHGVCFLAADTRGLVGQ LFCDFGEDFTVQDPTEAEPLTAAIQHISQGSPGILTLRK GANTHYFRDGDLVTFSGIEGMVELNDCDPRSIHVREDGS LEIGDTTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQP HVVAQSSQEVHHAHCLHQAFCALHKFQHLHGRPPQPWDP VDAETVVGLARDLEPLKRTEEEPLEEPLDEALVRTVALS SAGVLSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDA LDCLPEDGELLPSPEDCALRGSRYDGQIAVFGAGFQEKL RRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDM DHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQ VIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRY VAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPA SAAASEDAPYPVCTVRYFPSTAEHTLQWARHEFEELFRL SAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQ NWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTP FWSGPKQCPQPLEFDTNQDTHLLYVLAAANLYAQMHGLP GSQDWTALRELLKLLPQPDPQQMAPIFASNLELASASAE FGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDF VVAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAA VAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMP FAPAIQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQE QHGLRVRILLHGSALLYAAGWSPEKQAQHLPLRVTELVQ QLTGQAPAPGQRVLVLELSCEGDD

Database cross reference

RefSeq Protein accession:NP_003326
RefSeq Protein gi:38045948

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005829;C:cytosol;EXP:Reactome.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0019782;F:ISG15 activating enzyme activity;IDA:HGNC. GO:0016874;F:ligase activity;IEA:UniProtKB-KW.

GO-P

GO:0032020;P:ISG15-protein conjugation;IDA:HGNC. GO:0032480;P:negative regulation of type I interferon production;TAS:Reactome.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47933

PHOSPHORYLATION

896

Y

PhosphoSitePlus

13831836

LTP

N

HuLPr47933

PHOSPHORYLATION

892

Y

PhosphoSitePlus

1036863

LTP

N