Protein basic information
| LiverAtlas Protein ID |
HuLPr47939 |
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Uniprot ID |
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Uniprot Acc |
P0CG48;P02248;P02249;P02250;P62988;Q29120;Q6LBL4;Q6LDU5;Q8WYN8;Q91887;Q91888;Q9BWD6;Q9BX98;Q9UEF2;Q9UEG1;Q9UEK8;Q9UPK7; |
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Protein name |
Polyubiquitin-C |
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Comment |
FUNCTION:Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked:Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcript |
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Subcellular localization |
Ubiquitin:Cytoplasm(By similarity).Nucleus(By similarity). |
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Gene name |
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Related liver disease name |
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Protein sequence
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MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQI FVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR LIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFV KTLTGKTITLEVEPSDTIENVKAKIQDKEGIPSDQQRLI FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKT LTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFA GKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLT GKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGK TITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQL EDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTI TLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED GRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITL EVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGR TLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEV EPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTL SDYNIQKESTLHLVLRLRGGV |
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Database cross reference |
RefSeq Protein accession:NP_066289
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;EXP:Reactome. GO:0030666;C:endocytic vesicle membrane;TAS:Reactome. GO:0010008;C:endosome membrane;EXP:Reactome. GO:0005654;C:nucleoplasm;EXP:Reactome. GO:0005886;C:plasma membrane;TAS:Reactome. |
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GO-F |
GO:0005515;F:protein binding;IPI:BHF-UCL. |
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GO-P |
GO:0000187;P:activation of MAPK activity;TAS:Reactome. GO:0031145;P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;EXP:Reactome. GO:0006916;P:anti-apoptosis;EXP:Reactome. GO:0006915;P:apoptosis;EXP:Reactom |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr47939 |
PHOSPHORYLATION |
12 |
T |
PhosphoSitePlus |
LTP |
N |
 
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|
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HuLPr47939 |
PHOSPHORYLATION |
7 |
T |
PhosphoSitePlus |
LTP |
N |
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HuLPr47939 |
ACETYLATION |
6 |
K |
PhosphoSitePlus |
HTP |
N |
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HuLPr47939 |
ACETYLATION |
63 |
K |
PhosphoSitePlus |
HTP |
N |
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HuLPr47939 |
ACETYLATION |
48 |
K |
PhosphoSitePlus |
LTP HTP |
N |
|
|
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HuLPr47939 |
ACETYLATION |
33 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
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HuLPr47939 |
ACETYLATION |
11 |
K |
PhosphoSitePlus |
HTP |
N |
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HuLPr47939 |
ACETYLATION |
29 |
K |
PhosphoSitePlus |
LTP |
N |
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HuLPr47939 |
ACETYLATION |
27 |
K |
PhosphoSitePlus |
HTP |
N |
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HuLPr47939 |
UBIQUITINATION |
27 |
K |
PhosphoSitePlus |
HTP |
N |
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HuLPr47939 |
PHOSPHORYLATION |
59 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
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HuLPr47939 |
UBIQUITINATION |
6 |
K |
PhosphoSitePlus |
LTP |
N |
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HuLPr47939 |
UBIQUITINATION |
11 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr47939 |
UBIQUITINATION |
33 |
K |
PhosphoSitePlus |
LTP |
N |
|
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|
HuLPr47939 |
UBIQUITINATION |
48 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr47939 |
UBIQUITINATION |
63 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47939 |
UBIQUITINATION |
29 |
K |
PhosphoSitePlus |
LTP |
N |
|
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HuLPr47939 |
PHOSPHORYLATION |
57 |
S |
PhosphoSitePlus |
LTP |
N |
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