Protein basic information
| LiverAtlas Protein ID |
HuLPr47943 |
|
Uniprot ID |
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|
Uniprot Acc |
O15205;B0UZT6;Q5STL2;Q5SUK2;Q96EC7; |
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Protein name |
Ubiquitin D |
|
Comment |
FUNCTION:Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore loc |
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Subcellular localization |
Nucleus.Cytoplasm(By similarity). |
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Gene name |
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Protein sequence
|
MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSK TKVPVQDQVLLLGSKILKPRRSLSSYGIDKEKTIHLTLK VVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAM IETKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLF LACYCIGG |
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Database cross reference |
RefSeq Protein accession:NP_006389
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Ontology annotation
| GO-C |
GO:0016235;C:aggresome;IDA:UniProtKB. GO:0005737;C:cytoplasm;ISS:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB. |
|
GO-F |
GO:0070628;F:proteasome binding;IDA:UniProtKB. |
|
GO-P |
GO:0070842;P:aggresome assembly;IDA:UniProtKB. GO:0043011;P:myeloid dendritic cell differentiation;IMP:UniProtKB. GO:0035417;P:negative regulation of mitotic prometaphase;IMP:UniProtKB. GO:0043065;P:positive regulation of apoptosis;IMP:UniProtKB. GO:00 |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47943 |
PHOSPHORYLATION |
109 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr47943 |
PHOSPHORYLATION |
110 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr47943 |
PHOSPHORYLATION |
111 |
S |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
