Protein basic information
| LiverAtlas Protein ID |
HuLPr47958 |
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Uniprot ID |
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Uniprot Acc |
Q7Z3V4;A5D8Z3;Q05BX9;Q659F7;Q7Z7Q1;Q9BXZ4; |
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Protein name |
Ubiquitin-protein ligase E3B |
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Comment |
FUNCTION:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).||PATHWAY:Protein modification; protein ubiquitination.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=UBE3B v1; IsoId=Q7Z3V4-1; Sequence=Displayed; Note=Major isoform; Name=2; Synonyms=UBE3B v2; IsoId=Q7Z3V4-2; Sequence=VSP 024087, VSP 024088; Name=3; IsoId=Q7Z3V4-3; Sequence=VSP 024085, VSP 024086; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed.||SIMILARITY:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.||SIMILARITY:Contains 1 IQ domain. |
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Gene name |
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Protein sequence
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MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHV RSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKI ARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYV SLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSR LITLYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANI MGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSL ALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPER LTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLM GNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQK KSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGV PLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLL KRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQT SLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGL KLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIE VYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGE TLELFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSV LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKE KEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV FDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKM LGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVC HELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAA LISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLK KHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFV TSCSRPPLLGFAYLKPPFSIRCVE |
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Database cross reference |
RefSeq Protein accession:NP_569733
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver;Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005622;C:intracellular;IEA:InterPro. |
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GO-F |
GO:0004842;F:ubiquitin-protein ligase activity;ISS:RefGenome. |
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GO-P |
GO:0042787;P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process;ISS:RefGenome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr47958 |
PHOSPHORYLATION |
164 |
T |
Phospho-ELM |
HTP |
N |
 
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HuLPr47958 |
PHOSPHORYLATION |
419 |
S |
PhosphoSitePlus |
HTP |
N |
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