HuLPr47959

Uniprot ID

UBE3C_HUMAN

Uniprot Acc

Q15386;A4D235;A6NCP3;Q8TC15;Q96CR4;Q9UDU3;

Protein name

Ubiquitin-protein ligase E3C

Comment

FUNCTION:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Interacts with 26S proteasomes. Interacts (via the N- terminal) with CAND2; the interaction stimulates ubiquitination of CAND2 in vitro.||SUBCELLULAR LOCATION:Nucleus (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15386-1; Sequence=Displayed; Name=2; IsoId=Q15386-2; Sequence=VSP 013956, VSP 013957; Note=No experimental confirmation available; Name=3; IsoId=Q15386-3; Sequence=VSP 013953, VSP 013954, VSP 013955; Note=No experimental co

Subcellular localization

Nucleus(Potential).

Gene name

ubiquitin protein ligase E3C

Protein sequence

MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKRE EERRRLKNAIIIQSFIRGYRDRKQQYSIQRSAFDRCATL SQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLY QNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQN CNDDSLNVALPMRMLEVFSSENTYLPVLQDASYVVSVIE QILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAK ILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFT DQIFHFIIPALADAQTVFPYEPFLNALLLIESRCSRKSG GAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQL PVSPASASCHDSASDSEEESEEADKPSSPEDGRLSVSYI TEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCH TLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTR MITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFS HSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSR CLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSE MQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPN HWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQS TLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQ RLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSP ENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELL KSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYF LGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHL ASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQ VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCL AFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDL KSFTNYSGGYSADHPVIKVFWRVV

Database cross reference

RefSeq Protein accession:NP_055486
RefSeq Protein gi:187960100

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. GO:0000502;C:proteasome complex;IEA:UniProtKB-KW.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB. GO:0004842;F:ubiquitin-protein ligase activity;IDA:UniProtKB.

GO-P

GO:0000209;P:protein polyubiquitination;IDA:UniProtKB. GO:0042787;P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process;ISS:RefGenome.