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Protein basic information

LiverAtlas Protein ID

HuLPr47999

Uniprot ID

UBP34_HUMAN

Uniprot Acc

Q70CQ2;A8MWD0;B3KWU9;O60316;O94834;Q3B777;Q6P6C9;Q7L8P6;Q8N3T9;Q8TBW2;Q9UGA1;

Protein name

Ubiquitin carboxyl-terminal hydrolase 34

Comment

FUNCTION:Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.||CATALYTIC ACTIVITY:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).||SUBUNIT:Interacts with AXIN1 and AXIN2.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q70CQ2-1; Sequence=Displayed; Name=2; Iso

Gene name

ubiquitin specific peptidase 34

Protein sequence

MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINS WTQRQCLCCFKEYKHLEIFNQVVCALINLVIAQVQVLRD QLCKHCTTINIDSTWQDESNQAEEPLNIDRECNEGSTER QKSIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKL LLCVAKIFQIQFPLYTAYKHNTHPTIEDISTQESNILGA FCDMNDVEVPLHLLRYVCLFCGKNGLSLMKDCFEYGTPE TLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRTYVIR YLCKLSDQELRQSAARNMADLMWSTVKEPLDTTLCFDKE SLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDVCNNES LVSDTETSIAKELADWLISNNVVEHIFGPNLHIEIIKQC QVILNFLAAEGRLSTQHIDCIWAAAQLKHCSRYIHDLFP SLIKNLDPVPLRHLLNLVSALEPSVHTEQTLYLASMLIK ALWNNALAAKAQLSKQSSFASLLNTNIPIGNKKEEEELR RTAPSPWSPAASPQSSDNSDTHQSGGSDIEMDEQLINRT KHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHS DGSSNEVNSSHASQSAGSPGSEVQSEDIADIEALKEEDE DDDHGHNPPKSSCGTDLRNRKLESQAGICLGDSQGMSER NGTSSGTGKDLVFNTESLPSVDNRMRMLDACSHSEDPEH DISGEMNATHIAQGSQESCITRTGDFLGETIGNELFNCR QFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQV SAKSEKNMADFDGEESGCEEELVQINSHAELTSHLQQHL PNLASIYHEHLSQGPVVHKHQFNSNAVTDINLDNVCKKG NTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQ IRMRFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSS YDTHWITMWAEKELNMMKLFFDNLVYYIQTVREGRQKHA LYSHSAEVQVRLQFLTCVFSTLGS

Database cross reference

RefSeq Protein accession:NP_055524
RefSeq Protein gi:110347427

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-F

GO:0005488;F:binding;IEA:InterPro. GO:0008234;F:cysteine-type peptidase activity;IEA:UniProtKB-KW. GO:0004221;F:ubiquitin thiolesterase activity;IEA:InterPro.

GO-P

GO:0006511;P:ubiquitin-dependent protein catabolic process;IEA:InterPro.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr47999

PHOSPHORYLATION

3108

S

Phospho-ELM

36449

HTP

N

HuLPr47999

PHOSPHORYLATION

498

S

Phospho-ELM

20522

HTP

N

HuLPr47999

PHOSPHORYLATION

507

S

Phospho-ELM

20523

HTP

N

HuLPr47999

PHOSPHORYLATION

3207

S

PhosphoSitePlus

480000

LTP

N

HuLPr47999

PHOSPHORYLATION

3208

S

PhosphoSitePlus

480019

LTP

N

HuLPr47999

PHOSPHORYLATION

507

S

PhosphoSitePlus

478163

LTP

HTP

N

HuLPr47999

PHOSPHORYLATION

3230

T

PhosphoSitePlus

4742585

LTP

N

HuLPr47999

PHOSPHORYLATION

1307

S

PhosphoSitePlus

1233032

LTP

N

HuLPr47999

PHOSPHORYLATION

1310

S

PhosphoSitePlus

3203532

LTP

N

HuLPr47999

PHOSPHORYLATION

201

S

PhosphoSitePlus

3203544

LTP

N

HuLPr47999

PHOSPHORYLATION

2337

S

PhosphoSitePlus

454465

LTP

HTP

N

HuLPr47999

PHOSPHORYLATION

1600

S

PhosphoSitePlus

11952929

LTP

N

HuLPr47999

PHOSPHORYLATION

567

S

PhosphoSitePlus

11952930

LTP

HTP

N

HuLPr47999

PHOSPHORYLATION

37

T

PhosphoSitePlus

472588

LTP

N

HuLPr47999

PHOSPHORYLATION

1352

S

PhosphoSitePlus

2526337

LTP

HTP

N

HuLPr47999

ACETYLATION

3188

K

PhosphoSitePlus

14366493

LTP

HTP

N

HuLPr47999

PHOSPHORYLATION

3255

S

PhosphoSitePlus

477843

HTP

N

HuLPr47999

PHOSPHORYLATION

3213

T

PhosphoSitePlus

4949802

HTP

N

HuLPr47999

PHOSPHORYLATION

498

S

PhosphoSitePlus

481997

LTP

N