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Protein basic information

LiverAtlas Protein ID

HuLPr48006

Uniprot ID

UBP41_HUMAN

Uniprot Acc

Q3LFD5;A8MXD0;Q70BM7;

Protein name

Putative ubiquitin carboxyl-terminal hydrolase 41

Comment

FUNCTION:May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquinated proteins (By similarity).||CATALYTIC ACTIVITY:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).||SIMILARITY:Belongs to the peptidase C19 family.

Gene name

ubiquitin specific peptidase 41

Protein sequence

MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCERKEKASKQ ERENPLAHLAAWGLVGLHNIGQTCCLNSLIQVFVMNVDF ARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAV WPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIAD VHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLRL SFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGK KTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLY FPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGM ADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHW

Database cross reference

RefSeq Protein accession:XP_001718697
RefSeq Protein gi:310113998

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0008234;F:cysteine-type peptidase activity;IEA:UniProtKB-KW. GO:0004221;F:ubiquitin thiolesterase activity;IEA:InterPro.

GO-P

GO:0006511;P:ubiquitin-dependent protein catabolic process;IEA:InterPro.