Protein basic information
LiverAtlas Protein ID |
HuLPr48041 |
Uniprot ID |
|
Uniprot Acc |
Q14CS0;B3KWZ3; |
Protein name |
UBX domain-containing protein 2B |
Comment |
FUNCTION:Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.||SUBUNIT:Interacts with VCP. Does not bind ubiquitin (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity).||SIMILARITY:Belongs to the NSFL1C family.||SIMILARITY:Contains 1 SEP domain.||SIMILARITY:Contains 1 UBX domain. |
Subcellular localization |
Nucleus(By similarity).Cytoplasm, cytosol(By similarity).Endoplasmic reticulum(By similarity).Golgi apparatus(By similarity). |
Gene name |
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Protein sequence
|
MAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVK CKSSKSNRPKATVFKSPRTPPQRFYSSEHEYSGLNIVRP STGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGG GYRLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDD GELRPYNEPTNAQFLESVKRGEIPLELQRLVHGGQVNLD MEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSS PEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFN STHRILDVRNFIVQSRPEFAALDFILVTSFPNKELTDES LTLLEADILNTVLLQQLK |
Database cross reference |
RefSeq Protein accession:NP_001071087
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Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
French Liver;Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0005829;C:cytosol;IEA:UniProtKB-SubCell. GO:0005783;C:endoplasmic reticulum;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |