HuLPr48063

Uniprot ID

UD11_HUMAN

Uniprot Acc

P22309;

Protein name

UDP-glucuronosyltransferase 1-1

Comment

FUNCTION:UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.||CATALYTIC ACTIVITY:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.26 uM for bilirubin; Vmax=1080 pmol/min/mg enzyme with bilirubin as substrate;||SUBUNIT:Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.||SUBCELLULAR LOCATION:Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Po

Subcellular localization

Microsome.Endoplasmic reticulum membrane;Single-pass membrane protein(Potential).

Gene name

UDP glucuronosyltransferase 1 family, polypeptide A1

Related liver disease name

Gilbert syndrome

Crigler-Najjar syndrome, type 1

Arias syndrome

Lucey-Driscoll syndrome

Breast milk jaundice

Protein sequence

MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHW LSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTY PVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKK DSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCS PIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRP LSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLAS EFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVF VGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSE IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMM PLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAV INDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK GAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK CCAYGYRKCLGKKGRVKKAHKSKTH

Database cross reference

RefSeq Protein accession:NP_000454
RefSeq Protein gi:8850236

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

GO:0005789;C:endoplasmic reticulum membrane;TAS:Reactome. GO:0005792;C:microsome;IEA:UniProtKB-SubCell.

GO-F

GO:0019899;F:enzyme binding;IDA:BHF-UCL. GO:0004857;F:enzyme inhibitor activity;IDA:BHF-UCL. GO:0015020;F:glucuronosyltransferase activity;IDA:BHF-UCL. GO:0046982;F:protein heterodimerization activity;IPI:BHF-UCL. GO:0042803;F:protein homodimerization

GO-P

GO:0006789;P:bilirubin conjugation;TAS:ProtInc. GO:0007586;P:digestion;NAS:ProtInc. GO:0017144;P:drug metabolic process;IC:BHF-UCL. GO:0008210;P:estrogen metabolic process;TAS:ProtInc. GO:0051552;P:flavone metabolic process;IDA:BHF-UCL. GO:0042167;P:h