Protein basic information
| LiverAtlas Protein ID |
HuLPr48071 |
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Uniprot ID |
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Uniprot Acc |
O60656;P36509;Q9HAX0; |
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Protein name |
UDP-glucuronosyltransferase 1-9 |
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Comment |
FUNCTION:UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.||CATALYTIC ACTIVITY:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.||SUBCELLULAR LOCATION:Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues; Name=1; IsoId=O60656-1; Sequence=Displayed;||TISSUE SPECIFICITY:Liver.||SIMILARITY:Belongs to the UDP-glycosyltransferase family.||SEQUENCE CAUTION:Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82; |
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Subcellular localization |
Microsome.Endoplasmic reticulum membrane;Single-pass membrane protein(Potential). |
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Gene name |
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Protein sequence
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MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFT MRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYST SYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFD LFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIV AKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLG FSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEIL QTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGG INCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPE KKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIND KSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAP HLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCA YGYRKCLGKKGRVKKAHKSKTH |
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Database cross reference |
RefSeq Protein accession:NP_066307
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;NAS:UniProtKB. |
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GO-F |
GO:0019899;F:enzyme binding;IDA:BHF-UCL. GO:0004857;F:enzyme inhibitor activity;IDA:BHF-UCL. GO:0015020;F:glucuronosyltransferase activity;IDA:BHF-UCL. GO:0046982;F:protein heterodimerization activity;IPI:BHF-UCL. GO:0042803;F:protein homodimerization |
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GO-P |
GO:0017144;P:drug metabolic process;IDA:BHF-UCL. GO:0051552;P:flavone metabolic process;IDA:BHF-UCL. GO:0045922;P:negative regulation of fatty acid metabolic process;IDA:BHF-UCL. GO:0042573;P:retinoic acid metabolic process;IC:BHF-UCL. GO:0006805;P:xen |
