HuLPr48074

Uniprot ID

UD2B4_HUMAN

Uniprot Acc

P06133;O60731;O60867;O75614;P36538;Q1HBF9;

Protein name

UDP-glucuronosyltransferase 2B4

Comment

FUNCTION:UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.||CATALYTIC ACTIVITY:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.||SUBCELLULAR LOCATION:Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).||SIMILARITY:Belongs to the UDP-glycosyltransferase family.||CAUTION:PubMed:8333863 thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for another human enzyme.||WEB RESOURCE:Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ugt2b4/";

Subcellular localization

Microsome membrane;Single-pass membrane protein(Potential).Endoplasmic reticulum membrane;Single-pass membrane protein(Potential).

Gene name

UDP glucuronosyltransferase 2 family, polypeptide B4

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIK TILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPV SLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWT FNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFG ELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPV VMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQF YSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNV EFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMV SNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTR LYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMV GVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALK TVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMR HKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFII TKCLFCVWKFVRTGKKGKRD

Database cross reference

RefSeq Protein accession:NP_066962
RefSeq Protein gi:149944509

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;NAS:UniProtKB.

GO-F

GO:0015020;F:glucuronosyltransferase activity;IDA:BHF-UCL.

GO-P

GO:0006711;P:estrogen catabolic process;IDA:UniProtKB. GO:0006805;P:xenobiotic metabolic process;IDA:UniProtKB.