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Protein basic information

LiverAtlas Protein ID

HuLPr48075

Uniprot ID

UD2B7_HUMAN

Uniprot Acc

P16662;B2R810;Q6GTW0;

Protein name

UDP-glucuronosyltransferase 2B7

Comment

FUNCTION:UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.||FUNCTION:Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites.||CATALYTIC ACTIVITY:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.||SUBCELLULAR LOCATION:Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).||SIMILARITY:Belongs to the UDP-glycosyltransferase family.

Subcellular localization

Microsome membrane;Single-pass membrane protein(Potential).Endoplasmic reticulum membrane;Single-pass membrane protein(Potential).

Gene name

UDP glucuronosyltransferase 2 family, polypeptide B7

Protein sequence

MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIK TILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPT SLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSI FGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCS ELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPV VMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQF YSEVLGRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNV DFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMV SNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTR LYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMV GIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALK RVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMR HKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIV TKCCLFCFWKFARKAKKGKND

Database cross reference

RefSeq Protein accession:NP_001065
RefSeq Protein gi:190194389

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;IEA:UniProtKB-SubCell.

GO-F

GO:0015020;F:glucuronosyltransferase activity;IDA:BHF-UCL.

GO-P

GO:0006629;P:lipid metabolic process;TAS:ProtInc.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr48075

PHOSPHORYLATION

236

Y

PhosphoSitePlus

7378200

LTP

N

HuLPr48075

PHOSPHORYLATION

438

Y

PhosphoSitePlus

7378201

LTP

HTP

N