HuLPr48080

Uniprot ID

UDB15_HUMAN

Uniprot Acc

P54855;A6NDX0;A6NNJ4;P23765;Q9UK63;

Protein name

UDP-glucuronosyltransferase 2B15

Comment

FUNCTION:UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.||CATALYTIC ACTIVITY:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.||SUBCELLULAR LOCATION:Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).||TISSUE SPECIFICITY:Expressed in many tissues. Present in liver, prostate and testis.||SIMILARITY:Belongs to the UDP-glycosyltransferase family.||CAUTION:PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme.

Subcellular localization

Microsome membrane;Single-pass membrane protein(Potential).Endoplasmic reticulum membrane;Single-pass membrane protein(Potential).

Gene name

UDP glucuronosyltransferase 2 family, polypeptide B15

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMK TILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPT SLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCW EYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPC GELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVP VVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQ FYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPN VDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSM ISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNT RLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPM VGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNAL KSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVM RHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFI ITKFCLFCFRKLAKKGKKKKRD

Database cross reference

RefSeq Protein accession:NP_001067
RefSeq Protein gi:116517299

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;IEA:UniProtKB-SubCell.

GO-F

GO:0015020;F:glucuronosyltransferase activity;IDA:BHF-UCL.

GO-P

GO:0008202;P:steroid metabolic process;TAS:ProtInc. GO:0006805;P:xenobiotic metabolic process;TAS:ProtInc.