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Protein basic information

LiverAtlas Protein ID

HuLPr48090

Uniprot ID

UFSP2_HUMAN

Uniprot Acc

Q9NUQ7;Q6IA77;Q96FS3;

Protein name

Ufm1-specific protease 2

Comment

FUNCTION:Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity).||SUBUNIT:Interacts with DDRGK1 (By similarity).||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity).||SIMILARITY:Belongs to the peptidase C78 family.

Subcellular localization

Cytoplasm(By similarity).Endoplasmic reticulum(By similarity).Nucleus(By similarity).

Gene name

UFM1-specific peptidase 2

Protein sequence

MVISESMDILFRIRGGLDLAFQLATPNEIFLKKALKHVLS DLSTKLSSNALVFRICHSSVYIWPSSDINTIPGELTDAS ACKNILRFIQFEPEEDIKRKFMRKKDKKLSDMHQIVNID LMLEMSTSLAAVTPIIERESGGHHYVNMTLPVDAVISVA PEETWGKVRKLLVDAIHNQLTDMEKCILKYMKGTSIVVP EPLHFLLPGKKNLVTISYPSGIPDGQLQAYRKELHDLFN LPHDRPYFKRSNAYHFPDEPYKDGYIRNPHTYLNPPNME TGMIYVVQGIYGYHHYMQDRIDDNGWGCAYRSLQTICSW FKHQGYTERSIPTHREIQQALVDAGDKPATFVGSRQWIG SIEVQLVLNQLIGITSKILFVSQGSEIASQGRELANHFQ SEGTPVMIGGGVLAHTILGVAWNEITGQIKFLILDPHYT GAEDLQVILEKGWCGWKGPDFWNKDAYYNLCLPQRPNMI

Database cross reference

RefSeq Protein accession:NP_060829
RefSeq Protein gi:227498137

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005783;C:endoplasmic reticulum;ISS:UniProtKB. GO:0005634;C:nucleus;ISS:UniProtKB.

GO-F

GO:0019783;F:small conjugating protein-specific protease activity;ISS:UniProtKB.