Protein basic information
| LiverAtlas Protein ID |
HuLPr48107 |
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Uniprot ID |
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Uniprot Acc |
P11172;O00758;O00759;O00760;Q16862;Q9H3Q2;Q9UG49; |
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Protein name |
Uridine 5'-monophosphate synthase |
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Comment |
CATALYTIC ACTIVITY:Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.||CATALYTIC ACTIVITY:Orotidine 5'-phosphate = UMP + CO(2).||PATHWAY:Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate:step 1/2.||PATHWAY:Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate:step 2/2.||SUBUNIT:Homodimer.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11172-1; Sequence=Displayed; Name=2; IsoId=P11172-2; Sequence=VSP 009273; Note=No experimental confirmation available;||DISEASE:Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.||SIMILARITY:In the N-terminal sect |
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Gene name |
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Protein sequence
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MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDL RGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTAL PLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGET CLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQ GGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGR VKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPR IHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALG PSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDR KFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVK GLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAE EHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQ QYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKA AWEAYLSRLGV |
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Database cross reference |
RefSeq Protein accession:NP_000364
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;TAS:Reactome. GO:0005634;C:nucleus;IDA:UniProtKB. |
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GO-F |
GO:0004588;F:orotate phosphoribosyltransferase activity;IDA:UniProtKB. GO:0004590;F:orotidine-5'-phosphate decarboxylase activity;IDA:UniProtKB. |
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GO-P |
GO:0006207;P:'de novo' pyrimidine base biosynthetic process;IEA:InterPro. GO:0044205;P:'de novo' UMP biosynthetic process;IEA:InterPro. GO:0046134;P:pyrimidine nucleoside biosynthetic process;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr48107 |
PHOSPHORYLATION |
214 |
S |
Phospho-ELM |
HTP |
N |
 
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|
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HuLPr48107 |
PHOSPHORYLATION |
37 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48107 |
PHOSPHORYLATION |
214 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48107 |
ACETYLATION |
162 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48107 |
PHOSPHORYLATION |
444 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48107 |
PHOSPHORYLATION |
432 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr48107 |
PHOSPHORYLATION |
37 |
Y |
PhosphoSitePlus |
LTP |
N |
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