HuLPr48115

Uniprot ID

UNC5A_HUMAN

Uniprot Acc

Q6ZN44;B2RXE6;Q8TF26;Q96GP4;

Protein name

Netrin receptor UNC5A

Comment

FUNCTION:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.||SUBUNIT:Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein (By similarity). Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZN44-1; Sequence=Displayed; Note=No experimental confirmation available; Name=2; IsoId=Q6ZN44-2; Sequence=VSP 011694, VSP

Subcellular localization

Cell membrane;Single-pass type I membrane protein(By similarity).

Gene name

unc-5 homolog A (C. elegans)

Protein sequence

MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANP DLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNG EWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFG LEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLA KEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP NVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASA AVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNG GEECQGTDLDTRNCTSDLCVHTASGPEDVALYVGLIAVA VCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVS IKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPK FQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQN YFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDA IPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPP GVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDV LHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALS VAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEV VQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLW KSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSD LACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEA GVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLA QKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQL AAAVAGLGQPDAGLFTVSEAEC

Database cross reference

RefSeq Protein accession:NP_588610
RefSeq Protein gi:62243567

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;Chinese Liver;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-P

GO:0006915;P:apoptosis;TAS:Reactome. GO:0007411;P:axon guidance;TAS:Reactome. GO:0042981;P:regulation of apoptosis;TAS:Reactome.

Netrin-mediated_signaling_events