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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr48117

Uniprot ID

UNC5C_HUMAN

Uniprot Acc

O95185;Q8IUT0;

Protein name

Netrin receptor UNC5C

Comment

FUNCTION:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).||SUBUNIT:Interacts with the cytoplasmic part of DCC (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95185-1; Sequence=Displayed; Name=2; IsoId=O95185-2; Sequence=VSP 011700, VSP 011701;||TISSUE SPECIFICITY:Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.||PTM:Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation o

Subcellular localization

Membrane;Single-pass type I membrane protein(By similarity).

Gene name

unc-5 homolog C (C. elegans)

Protein sequence

MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAA QDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPV NLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLI VREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRK AYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPV AEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTA NYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNS RCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLC PVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDC DGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCL AISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKA ARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSP ILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQS LLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPN SGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQT LLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLK NQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENL STYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYC LDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLR LSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTF TLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPT GIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAP QTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEA QNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Database cross reference

RefSeq Protein accession:NP_003719
RefSeq Protein gi:302058265

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005042;F:netrin receptor activity;TAS:ProtInc.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0007411;P:axon guidance;TAS:Reactome. GO:0007420;P:brain development;TAS:ProtInc.

Pathway

Pathway name

Netrin-mediated_signaling_events