Protein basic information
| LiverAtlas Protein ID |
HuLPr48118 |
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Uniprot ID |
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Uniprot Acc |
Q6UXZ4;Q8WYP7; |
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Protein name |
Netrin receptor UNC5D |
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Comment |
FUNCTION:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).||SUBUNIT:Interacts with the cytoplasmic part of DCC (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6UXZ4-1; Sequence=Displayed; Name=2; IsoId=Q6UXZ4-2; Sequence=VSP 011703; Note=No experimental confirmation available;||PTM:Phosphorylated on cytoplasmic tyrosine residues (By similarity).||PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage |
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Subcellular localization |
Membrane;Single-pass type I membrane protein(By similarity). |
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Gene name |
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Protein sequence
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MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGE ALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARP AMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINV TRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYL RKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKN EEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAAN IVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQK RSRTCTNPAPLNGGAFCEGMSVQKITCTSLCPVDGSWEV WSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESE NCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVV AVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFK TVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELM TESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSR TFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGV FGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQG EPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCAD VSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPF ACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNS LDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLH FKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCS NRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQV QTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQ RICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPS AVILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL |
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Database cross reference |
RefSeq Protein accession:NP_543148
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0004872;F:receptor activity;IEA:UniProtKB-KW. |
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GO-P |
GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0007411;P:axon guidance;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48118 |
PHOSPHORYLATION |
210 |
T |
Phospho-ELM |
HTP |
N |
 
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HuLPr48118 |
PHOSPHORYLATION |
210 |
T |
PhosphoSitePlus |
LTP |
N |
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