HuLPr48123

Uniprot ID

UNKL_HUMAN

Uniprot Acc

Q9H9P5;B0QYN6;B1GXI8;Q96EV1;Q96RZ1;Q9BWL5;Q9H5K0;Q9UJJ8;

Protein name

RING finger protein unkempt-like

Comment

FUNCTION:May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Isoform 4 (C-terminal) interacts with the GTP-bound form of RAC1. Isoform 4 (C-terminal) interacts with SMARCD2/BAF60b.||SUBCELLULAR LOCATION:Isoform 4:Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Name=4; IsoId=Q9H9P5-4; Sequence=Displayed; Name=1; IsoId=Q9H9P5-1; Sequence=VSP 039433, VSP 039443; Name=2; IsoId=Q9H9P5-2; Sequence=VSP 039433; Name=3; IsoId=Q9H9P5-3; Sequence=VSP 039432, VSP 039441, VSP 039443; Name=5; IsoId=Q9H9P5-5; Sequence=VSP 039436, VSP 039437; Name=6; IsoId=Q9H9P5-6; Sequence=VSP 039434,

Subcellular localization

Isoform 4:Cytoplasm.Nucleus.

Gene name

unkempt homolog (Drosophila)-like

Protein sequence

MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFS QHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDV YCSKYNEATGVCPDGDECPYLHRTTGDTERKYHLRYYKT GTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVREL QAQEALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDP RWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDR RRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCH SRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLG MVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRG SEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGSGS SSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVN IASLEKDLEEQDGHDLGAAGPRSLAGSAPVAIPGSLPRA PSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQPPPL RSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPS PILSAGPPSSSSASPNGAELARVRRQLDEAKRKIRQWEE SWQQVKQVCDAWQREAQEAKERARVADSDRQLALQKKEE VEAQVIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCA ATAPECPYCKGQPLQW

Database cross reference

RefSeq Protein accession:NP_001032202
RefSeq Protein gi:80861489

HLPP validation

Yes/No

Yes

Project name

French Liver;Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0016874;F:ligase activity;IEA:UniProtKB-KW. GO:0003676;F:nucleic acid binding;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro.