HuLPr48157

Uniprot ID

UST_HUMAN

Uniprot Acc

Q9Y2C2;B2RCX6;

Protein name

Uronyl 2-sulfotransferase

Comment

FUNCTION:Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||TISSUE SPECIFICITY:Widely expressed.||SIMILARITY:Belongs to the sulfotransferase 3 family.

Subcellular localization

Golgi apparatus membrane;Single-pass type II membrane protein(By similarity).

Gene name

uronyl-2-sulfotransferase

Protein sequence

MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPF LRFSLRDYGFCMATLLVFCLGSLLYQLSGGPPRFLLDLR QYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTV VLLLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNIS TAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFL SNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILE NYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNV NENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPE HRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVK EQFHLLKRKFGLKSHVSKPPLRPHFFIPTPLETEEPIDD EEQDDEKWLEDIYKR

Database cross reference

RefSeq Protein accession:NP_005706
RefSeq Protein gi:5032219

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;TAS:ProtInc.

GO-F

GO:0008146;F:sulfotransferase activity;TAS:ProtInc.

GO-P

GO:0016051;P:carbohydrate biosynthetic process;IEA:InterPro. GO:0006477;P:protein sulfation;TAS:ProtInc.