Protein basic information
| LiverAtlas Protein ID |
HuLPr48174 |
|
Uniprot ID |
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|
Uniprot Acc |
Q8NBZ7;Q8NBX3;Q9H5C2; |
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Protein name |
UDP-glucuronic acid decarboxylase 1 |
|
Comment |
FUNCTION:Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.||CATALYTIC ACTIVITY:UDP-D-glucuronate = UDP-D-xylose + CO(2).||COFACTOR:NAD.||PATHWAY:Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate:step 1/1.||SUBUNIT:Interacts with AKT1 (By similarity).||SUBCELLULAR LOCATION:Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NBZ7-1; Sequence=Displayed; Name=2; IsoId=Q8NBZ7-2; Sequence=VSP 016757; Name=3; IsoId=Q8NBZ7-3; Sequence=VSP 016756;||SIMILARITY:Belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily. |
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Subcellular localization |
Golgi apparatus, Golgi stack membrane;Single-pass type II membrane protein(By similarity). |
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Gene name |
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Protein sequence
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MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNM RSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPP VKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVV DNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIY HLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGAR LLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGK RVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVV SNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALM NSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLS EAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYF RKELEYQANNQYIPKPKPARIKKGRTRHS |
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Database cross reference |
RefSeq Protein accession:NP_079352
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0032580;C:Golgi cisterna membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
|
GO-F |
GO:0050662;F:coenzyme binding;IEA:InterPro. GO:0048040;F:UDP-glucuronate decarboxylase activity;IEA:EC. |
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GO-P |
GO:0044237;P:cellular metabolic process;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48174 |
PHOSPHORYLATION |
175 |
T |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr48174 |
PHOSPHORYLATION |
94 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48174 |
PHOSPHORYLATION |
102 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48174 |
PHOSPHORYLATION |
105 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48174 |
PHOSPHORYLATION |
183 |
T |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
