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Protein basic information

LiverAtlas Protein ID

HuLPr48198

Uniprot ID

VASH1_HUMAN

Uniprot Acc

Q7L8A9;Q96H02;Q9UBF4;Q9Y629;

Protein name

Vasohibin-1

Comment

FUNCTION:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.||SUBCELLULAR LOCATION:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L8A9-1; Sequence=Displayed; Name=2; IsoId=Q7L8A9-2; Sequence=VSP 013324, VSP 013325;||TISSUE SPECIFICITY:Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.||INDUCTION:By VEGF.||PTM:2 major for

Subcellular localization

Secreted.

Gene name

vasohibin 1

Protein sequence

MPGGKKVAGGGSSGATPTSAAATAPSGVRRLETSEGTSAQ RDEEPEEEGEEDLRDGGVPFFVNRGGLPVDEATWERMWK HVAKIHPDGEKVAQRIRGATDLPKIPIPSVPTFQPSTPV PERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLA KEMTKEALPIKCLEAVILGIYLTNSMPTLERFPISFKTY FSGNYFRHIVLGVNFAGRYGALGMSRREDLMYKPPAFRT LSELVLDFEAAYGRCWHVLKKVKLGQSVSHDPHSVEQIE WKHSVLDVERLGRDDFRKELERHARDMRLKIGKGTGPPS PTKDRKKDVSSPQRAQSSPHRRNSRSERRPSGDKKTSEP KAMPDLNGYQIRV

Database cross reference

RefSeq Protein accession:NP_055724
RefSeq Protein gi:7662454

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005783;C:endoplasmic reticulum;IDA:UniProtKB. GO:0005615;C:extracellular space;IDA:UniProtKB.

GO-P

GO:0007050;P:cell cycle arrest;IEA:UniProtKB-KW. GO:0016525;P:negative regulation of angiogenesis;IDA:UniProtKB. GO:0043537;P:negative regulation of blood vessel endothelial cell migration;IDA:UniProtKB. GO:0001937;P:negative regulation of endothelial c