HuLPr48254

Uniprot ID

VINC_HUMAN

Uniprot Acc

P18206;Q16450;Q5SWX2;Q7Z3B8;Q8IXU7;

Protein name

Vinculin

Comment

FUNCTION:Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.||SUBUNIT:Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity).||INTERACTION:P54939:TLN1 (xeno); NbExp=1; IntAct=EBI-716775, EBI-1035421;||SUBCELLULAR LOCATION:Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization

Subcellular localization

Cytoplasm, cytoskeleton.Cell junction, adherens junction.Cell membrane;Peripheral membrane protein;Cytoplasmic side.

Gene name

vinculin

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDL TAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFI KVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSG TSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDL VTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMN TVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVE KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASID SKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELC AGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQK AQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAA QNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDD ILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATA LQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPT VDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDR VDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAR MQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEV FDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQAS VKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWI DNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMA NIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFRE AVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDS GYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELA PPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPM MMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAA GFPVPPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHRE ATKWSSKGNDIIAAAKRMALLMAE

Database cross reference

RefSeq Protein accession:NP_003364
RefSeq Protein gi:4507877

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Fetal Liver;Human Liver Organelles;Chinese Liver;

GO:0043034;C:costamere;ISS:UniProtKB. GO:0005829;C:cytosol;EXP:Reactome. GO:0005576;C:extracellular region;EXP:Reactome. GO:0005925;C:focal adhesion;ISS:UniProtKB.

GO-F

GO:0003779;F:actin binding;IEA:UniProtKB-KW. GO:0045294;F:alpha-catenin binding;IPI:UniProtKB. GO:0008013;F:beta-catenin binding;ISS:BHF-UCL. GO:0002166;F:beta-dystroglycan binding;IPI:UniProtKB. GO:0045296;F:cadherin binding;ISS:BHF-UCL. GO:0005198;F

GO-P