Protein basic information
| LiverAtlas Protein ID |
HuLPr48257 |
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Uniprot ID |
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Uniprot Acc |
Q6PFW1;O15082;Q5HYF8;Q7Z3A7;Q86TE7;Q86UV3;Q86UV4;Q86XW8;Q8IZN0; |
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Protein name |
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 |
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Comment |
FUNCTION:Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Activated when cells are exposed to hyperosmotic stress.||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).||CATALYTIC ACTIVITY:ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.12 uM for InsP6; KM=0.10 uM for |
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Subcellular localization |
Cytoplasm, cytosol. |
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Gene name |
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Protein sequence
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MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSE LLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLC RFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPL DKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGI DLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFV EKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSP ESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARK SPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFK QTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKI LGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMEL RCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKT GKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGK LEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDP QRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYP GGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTA AAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLS SCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLNS MTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQL YHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCV KYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISRE EKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLCYL RYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLD ETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPL SEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEE MKTNQGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRR SPLIRNRKAGSMEVLSETSSSRPG |
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Database cross reference |
RefSeq Protein accession:NP_001124330
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IDA:UniProtKB. |
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GO-F |
GO:0003993;F:acid phosphatase activity;IEA:InterPro. GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0033857;F:diphosphoinositol-pentakisphosphate kinase activity;IDA:UniProtKB. GO:0000827;F:inositol 1,3,4,5,6-pentakisphosphate kinase activity;IDA:UniProt |
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GO-P |
GO:0006020;P:inositol metabolic process;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr48257 |
PHOSPHORYLATION |
475 |
S |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr48257 |
PHOSPHORYLATION |
1152 |
S |
PhosphoSitePlus |
HTP |
N |
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HuLPr48257 |
PHOSPHORYLATION |
1149 |
T |
PhosphoSitePlus |
LTP |
N |
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HuLPr48257 |
PHOSPHORYLATION |
963 |
T |
PhosphoSitePlus |
HTP |
N |
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|
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HuLPr48257 |
PHOSPHORYLATION |
553 |
Y |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
