Protein basic information
| LiverAtlas Protein ID |
HuLPr48259 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9H9C1;O95434;Q9H7E1;Q9H9I9; |
|
Protein name |
VPS33B-interacting protein |
|
Comment |
FUNCTION:Plays a role in lysosomal trafficking. May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin.||SUBUNIT:Associates with the HOPS complex. Interacts with VPS33A and VPS33B. Interacts with RAB11A.||INTERACTION:Q91W86:Vps11 (xeno); NbExp=1; IntAct=EBI-749080, EBI-2527812; Q920Q4:Vps16 (xeno); NbExp=1; IntAct=EBI-749080, EBI-775797; Q8R307:Vps18 (xeno); NbExp=2; IntAct=EBI-749080, EBI-2527788; Q96AX1:VPS33A; NbExp=1; IntAct=EBI-749080, EBI-2527283; Q9H267:VPS33B; NbExp=4; IntAct=EBI-749080, EBI-749072; P49754:VPS41; NbExp=2; IntAct=EBI-749080, EBI-2130459;||SUBCELLULAR LOCATION:Early endosome. Recycling endosome. Late endosome.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H9C1-1; Sequence=Displayed; Name=2; IsoId=Q9H9C1-2; Sequence=VSP 009284; Note=No exper |
|
Subcellular localization |
Early endosome.Recycling endosome.Late endosome. |
|
Gene name |
VPS33B interacting protein, apical-basolateral polarity regulator |
|
Protein sequence
|
MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVN SLRDFVDDDDDDDLERVSWSGEPVGSISWSIRETAGNSG STHEGREQLKSRNSFSSYAQLPKPTSTYSLSSFFRGRTR PGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSP SDTVRRLRKGKVCSLERFRSLQDKLQLLEEAVSMHDGNV ITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIG DQKLLLDLFRFLDRTEELALSHYREHLNIQDPDKRKEFL KTCVGLPFSAEDSAHIQDHYTLLERQIIIEANDRHLESA GQTEIFRKHPRKASILNMPLVTTLFYSCFYHYTEAEGTF SSPVNLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFT TKNWLGYTKKRAPIGFHRVVEILHKNNAPVQILQEYVNL VEDVDTKLNLATKFKCHDVVIDTYRDLKDRQQLLAYRSK VDKGSAEEEKIDALLSSSQIRWKN |
|
Database cross reference |
RefSeq Protein accession:NP_001180243
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles;Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005769;C:early endosome;IDA:UniProtKB. GO:0005770;C:late endosome;IDA:UniProtKB. GO:0055037;C:recycling endosome;IDA:UniProtKB. |
|
GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. |
|
GO-P |
GO:0008333;P:endosome to lysosome transport;IMP:UniProtKB. GO:0006886;P:intracellular protein transport;IMP:UniProtKB. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48259 |
PHOSPHORYLATION |
117 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
121 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
124 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
132 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
11 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
11 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
126 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
130 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
93 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
132 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
121 |
S |
PhosphoSitePlus |
LTP HTP |
yes |
|
|
|
HuLPr48259 |
PHOSPHORYLATION |
124 |
S |
PhosphoSitePlus |
LTP |
yes |
|
