Protein basic information
| LiverAtlas Protein ID |
HuLPr48315 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q5VIR6;A8K2S8;Q8WYW3;Q9BRR2;Q9BY02;Q9NV25; |
|
Protein name |
Vacuolar protein sorting-associated protein 53 homolog |
|
Comment |
FUNCTION:May be involved in retrograde transport of early and late endosomes to the late Golgi.||SUBUNIT:Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS52, VPS53 and VPS54.||SUBCELLULAR LOCATION:Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=long; IsoId=Q5VIR6-1; Sequence=Displayed; Name=2; Synonyms=short; IsoId=Q5VIR6-2; Sequence=VSP 016236; Name=3; IsoId=Q5VIR6-3; Sequence=VSP 016237, VSP 016238; Note=No experimental confirmation available;||SIMILARITY:Belongs to the VPS53 family.||SEQUENCE CAUTION:Sequence=AAL55842.1; Type=Frameshift; Positions=562; |
|
Subcellular localization |
Golgi apparatus, trans-Golgi network membrane;Peripheral membrane protein.Endosome membrane;Peripheral membrane protein. |
|
Gene name |
|
|
Protein sequence
|
MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRA DFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNI RTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKA EKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAG GVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQ IRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPS NVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQE NQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMA ERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTT NFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPT PEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLY VYIESQDKNLGELIDRFVADFKAQGPPKPNTDEGGAVLP SCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREY AWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLE ELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERIN LTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSKMQW QNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFT QFCVKFANSFIPKFITHLFKCKPISMVGAEQVRWT |
|
Database cross reference |
RefSeq Protein accession:NP_001121631
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0010008;C:endosome membrane;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. |
|
GO-P |
GO:0015031;P:protein transport;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48315 |
ACETYLATION |
360 |
K |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr48315 |
ACETYLATION |
110 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48315 |
PHOSPHORYLATION |
580 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr48315 |
PHOSPHORYLATION |
391 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48315 |
PHOSPHORYLATION |
377 |
S |
PhosphoSitePlus |
LTP |
N |
|
