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Protein basic information

LiverAtlas Protein ID

HuLPr48341

Uniprot ID

VWA1_HUMAN

Uniprot Acc

Q6PCB0;A8K692;B3KUA1;Q7L5D7;Q9H6J5;

Protein name

von Willebrand factor A domain-containing protein 1

Comment

FUNCTION:Promotes matrix assembly (By similarity).||SUBUNIT:Homodimer or homomultimer. Interacts with HSPG2 (By similarity).||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix, basement membrane (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCB0-1; Sequence=Displayed; Name=2; IsoId=Q6PCB0-2; Sequence=VSP 028617;||PTM:N-glycosylated (By similarity).||SIMILARITY:Contains 2 fibronectin type-III domains.||SIMILARITY:Contains 1 VWFA domain.

Subcellular localization

Secreted, extracellular space, extracellular matrix, basement membrane(By similarity).

Gene name

von Willebrand factor A domain containing 1

Protein sequence

MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLD SSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVG SRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALV YAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQE LKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVD DLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPL LTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAGLD PDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGP ESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSW APALGSAAALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQ GLAPGTAYLVTVTAAFRSGRESALSAKACTPDGPRPRPR PVPRAPTPGTASREP

Database cross reference

RefSeq Protein accession:NP_073745
RefSeq Protein gi:40068485

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005604;C:basement membrane;IEA:UniProtKB-SubCell.