Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr48345

Uniprot ID

VWCE_HUMAN

Uniprot Acc

Q96DN2;A5PKV0;Q7Z7L6;Q86WK8;

Protein name

von Willebrand factor C and EGF domain-containing protein

Comment

FUNCTION:May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.||SUBCELLULAR LOCATION:Secreted (Potential). Note=According to PubMed:16496348 is localized in the cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96DN2-1; Sequence=Displayed; Name=2; IsoId=Q96DN2-2; Sequence=VSP 031230, VSP 031231; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in liver.||INDUCTION:By HBxAg.||SIMILARITY:Contains 4 EGF-like domains.||SIMILARITY:Contains 6 VWFC domains.||SEQUENCE CAUTION:Sequence=AAO47606.1; Type=Frameshift; Positions=210, 232, 745, 761, 769, 837, 912;

Subcellular localization

Secreted(Potential).

Gene name

von Willebrand factor C and EGF domains

Protein sequence

MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRL GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGI CIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGC QEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVN TEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKN SIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHH SCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAI LQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGV RTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLG NLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGA MHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIP SRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCL AGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWY ADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREE WRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPG DPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDC SAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPV DCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLD DEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSC PDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCS SCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGA HGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPL ASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEA SALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM

Database cross reference

RefSeq Protein accession:NP_689931
RefSeq Protein gi:114431244

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro.