Protein basic information
| LiverAtlas Protein ID |
HuLPr48349 |
|
Uniprot ID |
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|
Uniprot Acc |
Q9BUR4;B3KPR9;D3DTQ4;Q08ET9;Q9NW09; |
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Protein name |
Telomerase Cajal body protein 1 |
|
Comment |
FUNCTION:Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post- transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.||SUBUNIT:Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).||SUBCELLULAR LOCATION:Nucleus, Cajal body. Cytoplasm.||TISSUE SPECIFICITY:Expressed in all tissues and cell lines examined.||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.| |
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Subcellular localization |
Nucleus, Cajal body.Cytoplasm. |
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Gene name |
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Protein sequence
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MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSEL MPPPPERGDPPRLSPDPVAGSAVSQELREGDPVSLSTPL ETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEA NGPELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFL SGSWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIY NLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLM SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHL DELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCE VRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLY AWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAE LLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVS GSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSL HPSLPLLATASGQRVFPEPTESGDEGEELGLPLLSTRHV HLECRLQLWWCGGAPDSSIPDDHQGEKGQGGTEGGVGELI |
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Database cross reference |
RefSeq Protein accession:NP_001137462
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0015030;C:Cajal body;IDA:UniProtKB. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005697;C:telomerase holoenzyme complex;IDA:UniProtKB. |
|
GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. GO:0003723;F:RNA binding;IDA:UniProtKB. |
|
GO-P |
GO:0051973;P:positive regulation of telomerase activity;IDA:UniProtKB. GO:0032203;P:telomere formation via telomerase;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48349 |
PHOSPHORYLATION |
103 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
112 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
114 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
26 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
30 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
489 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
87 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
491 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
54 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
85 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
90 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
103 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
112 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
114 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
26 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
30 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
54 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
87 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
489 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
491 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
90 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
64 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
85 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48349 |
PHOSPHORYLATION |
16 |
S |
PhosphoSitePlus |
LTP |
N |
|
