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Protein basic information

LiverAtlas Protein ID

HuLPr48354

Uniprot ID

WASH4_HUMAN

Uniprot Acc

A8MWX3;

Protein name

Putative WAS protein family homolog 4

Comment

FUNCTION:Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity).||SUBUNIT:Component of the WASH complex, composed of F-actin- capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin- capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (By similarity).||SUBCELLULAR LOCATION:Early endosome membrane (By similarity). Recycling endosome membrane (By similarity). Note=Localization to the endodome membrane is mediated via its interaction with FAM21 (By similarity).||MISCELLANEOUS:WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose W

Subcellular localization

Early endosome membrane(By similarity).Recycling endosome membrane(By similarity).

Gene name

WAS protein family homolog 4 pseudogene

Protein sequence

MSGVMCLKASDTWASGIRSQPQGCLGKWRSMRCKHTRMHL AHLGNSRQLISLGPPRTREDGSRISQQVEQSRSQVQAIG EKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGS IFTDAQDPGLQRRPRHRIQSKQRPLDERALQEKLKDFPV CVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLY KKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKRE QLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGIANDLM YIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGV LTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDD SSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKA KLRSMKERKLEKQQQKEQEQVRATSQGGHLMSDLFNKLV MRRKGISGKGPGAGDGPGGAFARVSDSIPPLPPPQQPQAEDEDDWES

Database cross reference


Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;

Ontology annotation

GO-C

GO:0031901;C:early endosome membrane;IEA:UniProtKB-SubCell. GO:0055038;C:recycling endosome membrane;IEA:UniProtKB-SubCell. GO:0071203;C:WASH complex;ISS:UniProtKB.

GO-F

GO:0003779;F:actin binding;IEA:UniProtKB-KW. GO:0043014;F:alpha-tubulin binding;ISS:UniProtKB.

GO-P

GO:0034314;P:Arp2/3 complex-mediated actin nucleation;ISS:UniProtKB. GO:0042147;P:retrograde transport, endosome to Golgi;ISS:UniProtKB.