Protein basic information
| LiverAtlas Protein ID |
HuLPr48355 |
|
Uniprot ID |
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Uniprot Acc |
Q9NQA3;A6NGF1;Q8N305; |
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Protein name |
WAS protein family homolog 6 |
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Comment |
FUNCTION:Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity).||SUBUNIT:Component of the WASH complex, composed of F-actin- capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin- capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (By similarity).||SUBCELLULAR LOCATION:Early endosome membrane (By similarity). Recycling endosome membrane (By similarity). Note=Localization to the endodome membrane is mediated via its interaction with FAM21 (By similarity).||MISCELLANEOUS:WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose W |
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Subcellular localization |
Early endosome membrane(By similarity).Recycling endosome membrane(By similarity). |
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Gene name |
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Protein sequence
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MAFHEMQAHKNALGTSGEQQAADITGPTPHQGGWKQVEQS RSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAP ERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQ EKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLL FNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDA PLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDL PSIANDLMYSADLGPGIAPSAPGTIPELPTFHTEVAEPL KADLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPV GQGARQDDGSSSASPSVQGAPREVVDPSGGWATLLESIR QAGGIGKAKLRSMKERKLEKKKQKEQEQVRATSQGGHLM SDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPV PPPQQPQAEEDEDDWES |
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Database cross reference |
Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver; |
Ontology annotation
| GO-C |
GO:0031901;C:early endosome membrane;IEA:UniProtKB-SubCell. GO:0055038;C:recycling endosome membrane;IEA:UniProtKB-SubCell. GO:0071203;C:WASH complex;ISS:UniProtKB. |
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GO-F |
GO:0003779;F:actin binding;IEA:UniProtKB-KW. GO:0043014;F:alpha-tubulin binding;ISS:UniProtKB. |
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GO-P |
GO:0034314;P:Arp2/3 complex-mediated actin nucleation;ISS:UniProtKB. GO:0042147;P:retrograde transport, endosome to Golgi;ISS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48355 |
PHOSPHORYLATION |
327 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr48355 |
PHOSPHORYLATION |
199 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48355 |
PHOSPHORYLATION |
201 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48355 |
PHOSPHORYLATION |
385 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48355 |
PHOSPHORYLATION |
392 |
S |
PhosphoSitePlus |
HTP |
N |
|
