HuLPr48366

Uniprot ID

WDFY1_HUMAN

Uniprot Acc

Q8IWB7;Q9H9D5;Q9P2B3;

Protein name

WD repeat and FYVE domain-containing protein 1

Comment

SUBUNIT:Binds PtdIns3P in vitro with high specificity over other phosphoinositides.||SUBCELLULAR LOCATION:Early endosome.||DOMAIN:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.||SIMILARITY:Contains 1 FYVE-type zinc finger.||SIMILARITY:Contains 7 WD repeats.||SEQUENCE CAUTION:Sequence=BAA92673.1; Type=Erroneous initiation;

Subcellular localization

Early endosome.

Gene name

WD repeat and FYVE domain containing 1

Protein sequence

MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVI TASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHD SRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVS AIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSW ASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLK GHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRT LLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVS REEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHH CRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIK DEDRTSLATFHEGKHNISHMSMDIARGLMVTCGTDRIVK IWDMTPVVGCSLATGFSPH

Database cross reference

RefSeq Protein accession:NP_065881
RefSeq Protein gi:18482373

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005829;C:cytosol;IDA:UniProtKB. GO:0005769;C:early endosome;IDA:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB.

GO-F

GO:0005545;F:1-phosphatidylinositol binding;IDA:UniProtKB. GO:0008270;F:zinc ion binding;NAS:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr48366

PHOSPHORYLATION

408

S

PhosphoSitePlus

454530

LTP

HTP

N

IL2