HuLPr48375

Uniprot ID

WDR16_HUMAN

Uniprot Acc

Q8N1V2;B2RDU7;Q5DX23;Q8TC73;Q8TCI3;

Protein name

WD repeat-containing protein 16

Comment

FUNCTION:May play an essential role in the growth or survival of hepatocellular carcinoma (HCC).||SUBCELLULAR LOCATION:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N1V2-1; Sequence=Displayed; Name=2; IsoId=Q8N1V2-2; Sequence=VSP 018067; Note=No experimental confirmation available; Name=3; IsoId=Q8N1V2-3; Sequence=VSP 018068; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in testis. Up-regulated in hepatocellular carcinoma (HCC).||MISCELLANEOUS:May be a good candidate as a diagnostic marker for HCC as well as a potential molecular target for development of novel therapeutic drugs.||SIMILARITY:Contains 11 WD repeats.||SEQUENCE CAUTION:Sequence=BAB85083.1; Type=Frameshift; Positions=183;

Subcellular localization

Cytoplasm.

Gene name

WD repeat domain 16

Protein sequence

MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMI YPLGCTVLIQAINTKEQNFLQGHGNNVSCLAISRSGEYI ASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALA FSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLN VGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWP TECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPR TKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLV FCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESH IYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCA KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIIS AWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCK RVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCV CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS INGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGH SGNITRIRISPGNQYIVSVSADGAILRWKYPYTS

Database cross reference

RefSeq Protein accession:NP_001074025
RefSeq Protein gi:124028510

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IDA:HPA. GO:0043231;C:intracellular membrane-bounded organelle;IDA:HPA.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.