Protein basic information
| LiverAtlas Protein ID |
HuLPr48507 |
|
Uniprot ID |
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Uniprot Acc |
Q6GPH4;A2T931;A2T932;A8K2L1;A8K9Y3;D3DTM6;Q6MZE8;Q8N557;Q99982; |
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Protein name |
XIAP-associated factor 1 |
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Comment |
FUNCTION:Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.||SUBUNIT:Interacts with BIRC |
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Subcellular localization |
Cytoplasm.Nucleus.Mitochondrion. |
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Gene name |
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Protein sequence
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MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEP VPKETMEEHCKLEHQQVGCTMCQQSMQKSSLEFHKANEC QERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQF IMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCN QMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPS QAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSK NKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILL PLPILNQHQEKCRWLASSKGKQVRNFS |
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Database cross reference |
RefSeq Protein accession:NP_059993
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005739;C:mitochondrion;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0060337;P:type I interferon-mediated signaling pathway;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48507 |
PHOSPHORYLATION |
152 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr48507 |
PHOSPHORYLATION |
155 |
Y |
PhosphoSitePlus |
LTP |
N |
|
