HuLPr48539

Uniprot ID

XPR1_HUMAN

Uniprot Acc

Q9UBH6;O95719;Q7L8K9;Q8IW20;Q9NT19;Q9UFB9;

Protein name

Xenotropic and polytropic retrovirus receptor 1

Comment

FUNCTION:May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBH6-1; Sequence=Displayed; Name=2; IsoId=Q9UBH6-2; Sequence=VSP 030748;||TISSUE SPECIFICITY:Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.||DEVELOPMENTAL STAGE:Expressed in fetal liver.||SIMILARITY:Belongs to the SYG1 (TC 2.A.94) family.||SIMILARITY:Contains 1 EXS domain.||SIMILARITY:Contains 1 SPX domain.||CAUTION:It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human.

Subcellular localization

Cell membrane;Multi-pass membrane protein(Probable).

Gene name

xenotropic and polytropic retrovirus receptor 1

Protein sequence

MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVE VTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAE AQRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLS HEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFR KILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLIS ETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTF RVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRG GFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSH QHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALY GFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGF ADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLL PNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRD TKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTM VFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFL REEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLP HSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRA VRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRSWKYN QSISLRRPRLASQSKARDTKVLIEDTDDEANT

Database cross reference

RefSeq Protein accession:NP_001129141
RefSeq Protein gi:208609982

GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0004930;F:G-protein coupled receptor activity;TAS:ProtInc.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr48539

PHOSPHORYLATION

666

S

PhosphoSitePlus

1211778

HTP

N

HuLPr48539

PHOSPHORYLATION

660

S

PhosphoSitePlus

9511917

HTP

N

HuLPr48539

PHOSPHORYLATION

668

S

PhosphoSitePlus

3214809

LTP

N

HuLPr48539

PHOSPHORYLATION

690

T

PhosphoSitePlus

471521

LTP

HTP

N