Protein basic information
| LiverAtlas Protein ID |
HuLPr48576 |
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Uniprot ID |
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Uniprot Acc |
Q9Y2T7;D3DTP1;Q8N4P0; |
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Protein name |
Y-box-binding protein 2 |
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Comment |
FUNCTION:Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).||SUBUNIT:Found in a mRNP complex with PABPC1 and CSDA (By similarity).||SUBCELLULAR LOCATION:Cytoplasm. Nucleus.||TISSUE SPECIFICITY:Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary art |
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Subcellular localization |
Cytoplasm.Nucleus. |
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Gene name |
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Protein sequence
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MSEVEAAAGATAVPAATVPATAAGVVAVVVPVPAGEPQKG GGAGGGGGAASGPAAGTPSAPGSRTPGNPATAVSGTPAP PARSQADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKED VFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEA TNVTGPGGVPVKGSRYAPNRRKSRRFIPRPPSVAPPPMV AEIPSAGTGPGSKGERAEDSGQRPRRWCPPPFFYRRRFV RGPRPPNQQQPIEGTDRVEPKETAPLEGHQQQGDERVPP PRFRPRYRRPFRPRPRQQPTTEGGDGETKPSQGPADGSR PEPQRPRNRPYFQRRRQQAPGPQQAPGPRQPAAPETSAP VNSGDPTTTILE |
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Database cross reference |
RefSeq Protein accession:NP_057066
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;TAS:ProtInc. GO:0005634;C:nucleus;TAS:ProtInc. |
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GO-F |
GO:0003677;F:DNA binding;IEA:UniProtKB-KW. |
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GO-P |
GO:0006355;P:regulation of transcription, DNA-dependent;IEA:InterPro. GO:0006366;P:transcription from RNA polymerase II promoter;TAS:ProtInc. GO:0009386;P:translational attenuation;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48576 |
ACETYLATION |
116 |
K |
PhosphoSitePlus |
LTP |
N |
 
|
|
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HuLPr48576 |
PHOSPHORYLATION |
137 |
S |
PhosphoSitePlus |
LTP HTP |
N |
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