HuLPr48638

Uniprot ID

YKT6_HUMAN

Uniprot Acc

O15498;Q53F01;Q6FGU9;Q6IB15;

Protein name

Synaptobrevin homolog YKT6

Comment

FUNCTION:Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.||SUBUNIT:Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5 (By similarity).||SUBCELLULAR LOCATION:Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.||DOMAIN:The longin domain regulates palmitoylation and membrane targeting.||PTM:Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targetin

Subcellular localization

Cytoplasm, cytosol.Cytoplasmic vesicle membrane;Lipid-anchor;Cytoplasmic side.Golgi apparatus membrane;Lipid-anchor;Cytoplasmic side.

Gene name

YKT6 v-SNARE homolog (S. cerevisiae)

Protein sequence

MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFM TFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVV IADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATI HYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTM ESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

Database cross reference

RefSeq Protein accession:NP_006546
RefSeq Protein gi:5730120

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0030659;C:cytoplasmic vesicle membrane;IEA:UniProtKB-SubCell. GO:0005829;C:cytosol;IEA:UniProtKB-SubCell. GO:0005783;C:endoplasmic reticulum;IDA:HGNC. GO:0005768;C:endosome;IDA:HGNC. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0005887;C:i

GO-F

GO:0019706;F:protein-cysteine S-palmitoleyltransferase activity;IDA:HGNC. GO:0005484;F:SNAP receptor activity;IDA:HGNC.

GO-P

GO:0006888;P:ER to Golgi vesicle-mediated transport;IDA:HGNC. GO:0015031;P:protein transport;IEA:UniProtKB-KW. GO:0042147;P:retrograde transport, endosome to Golgi;IDA:HGNC. GO:0006904;P:vesicle docking involved in exocytosis;IDA:HGNC. GO:0006903;P:ves