HuLPr48733

Uniprot ID

ZACN_HUMAN

Uniprot Acc

Q401N2;Q2TB29;Q6ZWK3;Q86YW4;

Protein name

Zinc-activated ligand-gated ion channel

Comment

FUNCTION:Zinc-activated ligand-gated ion channel.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q401N2-1; Sequence=Displayed; Name=2; IsoId=Q401N2-2; Sequence=VSP 030911, VSP 030912; Name=3; IsoId=Q401N2-3; Sequence=VSP 030909, VSP 030910; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay;||TISSUE SPECIFICITY:Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.||PTM:Glycosylated.||MISCELLANEOUS:The mouse and rat orthologous proteins do not exist.||SIMILARITY:Belongs to the ligand-gated ion channel (TC 1.A.9) family.||CAUTION:It is uncertain whether Met-1 or Met-2 is the initiator.||SEQUENCE CAUTION:Sequence=AAI10598

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

zinc activated ligand-gated ion channel

Protein sequence

MMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNV NLSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRY TMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTP RLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNC NFELLHFPRDHSNCSLSFYALSNTAMELEFQAHVVNEIV SVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSII ALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLV LHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVL LAGLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPS RGVKGSQRSWPETADRIFFLVYVVGVLCTQFVFAGIWMW AACKSDAAPGEAAPHGRRPRL

Database cross reference

RefSeq Protein accession:NP_851321
RefSeq Protein gi:206725456

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005624;C:membrane fraction;IDA:HGNC. GO:0005886;C:plasma membrane;IDA:HGNC. GO:0045211;C:postsynaptic membrane;IEA:InterPro.

GO-F

GO:0005230;F:extracellular ligand-gated ion channel activity;IEA:InterPro. GO:0004872;F:receptor activity;IEA:UniProtKB-KW. GO:0008270;F:zinc ion binding;IC:HGNC.

GO-P

GO:0010043;P:response to zinc ion;IDA:HGNC.