HuLPr48787

Uniprot ID

ZC12D_HUMAN

Uniprot Acc

A2A288;A1L178;B2RXF4;B9ZZP9;B9ZZQ0;Q6ZRW2;

Protein name

Probable ribonuclease ZC3H12D

Comment

FUNCTION:May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.||COFACTOR:Magnesium (Potential).||SUBCELLULAR LOCATION:Isoform 1:Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, EIF2C2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.||SUBCELLULAR LOCATION:Isoform 3:Cytoplasm. Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=P58TFL, TFL1; IsoId=A2A288-1; Sequence=Displayed; Name=2; IsoId=A2A288-3; Sequence=VSP 052853; Note=No experimental confirmation available; Name=3; Synonyms=P36TFL, TFL2; IsoId=A2A288-4; Sequence=VSP 040794, VSP 040795; Note=Ref.1 (BAH28269) sequence is in conflict in positions: 300:V->G, 301:L->V, 30

Subcellular localization

Isoform 1:Cytoplasm.

Gene name

zinc finger CCCH-type containing 12D

Protein sequence

MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQEL IRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALE EDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAV DWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELE RQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVS NDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPL GRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKF YHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPG GSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFS DDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSL PSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPR RPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYA TEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLA RLILLVQRCQSAGAPLGKP

Database cross reference

RefSeq Protein accession:NP_997243
RefSeq Protein gi:282394049

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0004519;F:endonuclease activity;IEA:UniProtKB-KW. GO:0003676;F:nucleic acid binding;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr48787

PHOSPHORYLATION

182

Y

PhosphoSitePlus

1019140

LTP

HTP

N