Protein basic information
| LiverAtlas Protein ID |
HuLPr48792 |
|
Uniprot ID |
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Uniprot Acc |
Q8N5P1;Q9BZ75; |
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Protein name |
Zinc finger CCCH domain-containing protein 8 |
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Comment |
FUNCTION:Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.||SUBCELLULAR LOCATION:Nucleus (By similarity).||DOMAIN:The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression.||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Contains 3 C3H1-type zinc fingers.||SEQUENCE CAUTION:Sequence=AAH32001.1; Type=Frameshift; Positions=291; |
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Subcellular localization |
Nucleus(By similarity). |
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Gene name |
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Protein sequence
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MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEE KIKLECEQIPKKFRHSAISPKSSLHRKSRSKDYDVYSDN DICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGV KDTPQAAKQKNKNLKAGHKNGKQKKMKRKWPGPGNKGSN ALLRNSGSQEEDGKPKEKQQHLSQAFINQHTVERKGKQI CKYFLERKCIKGDQCKFDHDAEIEKKKEMCKFYVQGYCT RGENCLYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPE TQELLAKVLDTEKKSCK |
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Database cross reference |
RefSeq Protein accession:NP_115883
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;ISS:UniProtKB. |
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GO-F |
GO:0003723;F:RNA binding;IEA:UniProtKB-KW. GO:0043565;F:sequence-specific DNA binding;ISS:UniProtKB. GO:0003700;F:sequence-specific DNA binding transcription factor activity;IMP:UniProtKB. GO:0016566;F:specific transcriptional repressor activity;IDA:Uni |
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GO-P |
GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0033085;P:negative regulation of T cell differentiation in thymus;IMP:UniProtKB. GO:0045892;P:negative regulation of transcription, DNA-dependent;ISS:UniProtKB. GO:0070245;P:positive regulation of thymocyte ap |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48792 |
PHOSPHORYLATION |
32 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
76 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
77 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
83 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
77 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
83 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
22 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
199 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
56 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
59 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48792 |
PHOSPHORYLATION |
32 |
T |
PhosphoSitePlus |
HTP |
N |
|
