Protein basic information
| LiverAtlas Protein ID |
HuLPr48869 |
|
Uniprot ID |
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|
Uniprot Acc |
Q96JP5;A6NHC4;A8MSG7;Q86V47;Q96JP4;Q96QA3; |
|
Protein name |
E3 ubiquitin-protein ligase ZFP91 |
|
Comment |
FUNCTION:Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Interacts with MAP3K14/NIK.||SUBCELLULAR LOCATION:Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96JP5-1; Sequence=Displayed; Name=2; IsoId=Q96JP5-2; Sequence=VSP 012686, VSP 012687;||TISSUE SPECIFICITY:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.||MISCELLANEOUS:In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.||SIMILARITY:Belongs to the krueppel C2H2-type zinc-finger protein family.||SIMILARITY:Contains 5 C2H2-type zin |
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Subcellular localization |
Nucleus. |
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Gene name |
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Protein sequence
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MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAA PAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRR RRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEK VTTDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRT SVSRHRDTENTRSSRSKTGSLQLICKSEPNTDQLDYDVG EEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETY KPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEE NEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRC EMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRL FRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHR MIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQF SCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGAL ITSTDILGTNPESLTQPSDGQGLPLLPEPLGNSTSGECL LLEAEGMSKSYCSGTERVSLMADGKIFVGSGSSGGTEGL VMNSDILGATTEVLIEDSDSAGP |
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Database cross reference |
RefSeq Protein accession:NP_001183980
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IDA:HPA. |
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GO-F |
GO:0003676;F:nucleic acid binding;IEA:InterPro. GO:0004842;F:ubiquitin-protein ligase activity;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
|
GO-P |
GO:0007250;P:activation of NF-kappaB-inducing kinase activity;IDA:UniProtKB. GO:0070534;P:protein K63-linked ubiquitination;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr48869 |
PHOSPHORYLATION |
395 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
82 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
83 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
85 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
101 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
103 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
296 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
367 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
101 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
103 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
83 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
82 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
85 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr48869 |
PHOSPHORYLATION |
395 |
T |
PhosphoSitePlus |
HTP |
N |
|
