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Protein basic information

LiverAtlas Protein ID

HuLPr48878

Uniprot ID

ZFY21_HUMAN

Uniprot Acc

Q9BQ24;A8K3A4;Q86T05;Q96LT1;

Protein name

Zinc finger FYVE domain-containing protein 21

Comment

FUNCTION:Plays a role in cell adhesion, and thereby in cell motility, regulating microtubule-induced PTK2/FAK dephosphorylation, an event important for focal adhesion disassemblya, as well as integrin beta-1/ITGB1 cell surface expression.||SUBUNIT:Interacts with PTK2/FAK.||SUBCELLULAR LOCATION:Cell junction, focal adhesion. Cytoplasmic vesicle. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BQ24-1; Sequence=Displayed; Name=2; IsoId=Q9BQ24-2; Sequence=VSP 013794; Note=No experimental confirmation available;||SIMILARITY:Contains 1 FYVE-type zinc finger.||SEQUENCE CAUTION:Sequence=CAD62589.1; Type=Erroneous initiation;

Subcellular localization

Cell junction, focal adhesion.Cytoplasmic vesicle.

Gene name

zinc finger, FYVE domain containing 21

Protein sequence

MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQ WVPDKECRRCMQCDAKFDFLTRKHHCRRCGKCFCDRCCS QKVPLRRMCFVDPVRQCAECALVSLKEAEFYDKQLKVLL SGATFLVTFGNSEKPETMTCRLSNNQRYLFLDGDSHYEI EIVHISTVQILTEGFPPGGGNARATGMFLQYTVPGTEGV TQLKLTVVEDVTVGRRQAVAWLVAMHKAAKLLYESRDQ

Database cross reference

RefSeq Protein accession:NP_001185882
RefSeq Protein gi:312147341

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016023;C:cytoplasmic membrane-bounded vesicle;IEA:UniProtKB-SubCell. GO:0005925;C:focal adhesion;IEA:UniProtKB-SubCell.

GO-F

GO:0008270;F:zinc ion binding;IEA:InterPro.