Protein basic information
| LiverAtlas Protein ID |
HuLPr48879 |
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Uniprot ID |
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Uniprot Acc |
Q68DK2;B1B5Y3;B4E2U3;O15035;Q68DT9;Q6AW90;Q6ZR50;Q7Z3A4;Q7Z3I1;Q8N4W7; |
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Protein name |
Zinc finger FYVE domain-containing protein 26 |
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Comment |
FUNCTION:Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis:recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.||SUBUNIT:Interacts with KIAA0415, DKFZp761E198, C20orf29 and SPG11. Interacts with TTC19 and KIF13A.||SUBCELLULAR LOCATION:Cytoplasm, cytoskeleton, centrosome. Midbody. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q68DK2-1; Sequence=Displayed; Name=2; IsoId=Q68DK2-2; Sequence=VSP 030339; Note=No experimental confirmation available; Name=4; IsoId=Q68DK2-4; Sequence=VSP 041049, VSP 041050; Note=No experimental confirmation available; Name=3; IsoId=Q68DK2-3; Sequence=VSP 030338, VSP 030340, VSP 030341; Note=No experimental confirmation availa |
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Subcellular localization |
Cytoplasm, cytoskeleton, centrosome.Midbody. |
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Gene name |
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Protein sequence
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MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQ EGQGDIPKRVEDILQALVVCPNLLRCGQDINPQRVAWVW LLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPEN ILEELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVL WDLLRQSPQPAQALLELLLEEDDGTGLCHWPLQNALVDL IRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVE LHLLCEELLEACRTEGSPLREERLLSCLLHKASRGLLSL YGHTYAEKVTEKPPRATASGKVSPDHLDPERAMLALFSN PNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFP NLGCLLDREFRPLSCLLVLLGWTHCQSLESAKRLLQTLH RTQGPGCDELLRDACDGLWAHLEVLEWCIQQSSNPIPKR DLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKV PAKDPQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYAI YALCVNSHQHSQCQDCKDSLSEDLASATEPANDSLSSPG AANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITS ADLHPEPHLPEDYAEDDDIEGKSPSGLRSPSESPQHIAH PERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGPHRHS FLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRS PPEKPKQESQSCSGSRDGLQSRLHRLSKVVSEAQWRHKV VTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRD RGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPH PQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLK SSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSST IRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSG DPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFD LACSQCQLWKTCKQLLETAERRLN |
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Database cross reference |
RefSeq Protein accession:NP_056161
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Ontology annotation
| GO-C |
GO:0005813;C:centrosome;IDA:UniProtKB. GO:0030496;C:midbody;IDA:UniProtKB. |
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GO-F |
GO:0032266;F:phosphatidylinositol-3-phosphate binding;IDA:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0008219;P:cell death;IEA:UniProtKB-KW. GO:0000910;P:cytokinesis;IMP:UniProtKB. GO:0000724;P:double-strand break repair via homologous recombination;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr48879 |
ACETYLATION |
2416 |
K |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr48879 |
PHOSPHORYLATION |
873 |
Y |
PhosphoSitePlus |
HTP |
N |
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