HuLPr48908

Uniprot ID

ZMIZ2_HUMAN

Uniprot Acc

Q8NF64;A4D2K7;D3DVL1;O94790;Q0VGB4;Q659A8;Q6JKL5;Q8WTX8;Q96Q01;Q9BQH7;

Protein name

Zinc finger MIZ domain-containing protein 2

Comment

FUNCTION:Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.||SUBUNIT:Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.||SUBCELLULAR LOCATION:Nucleus. Note=Detected at replication foci throughout S phase.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NF64-1; Sequence=Displayed; Name=2; IsoId=Q8NF64-2; Sequence=VSP 012190; Name=3; IsoId=Q8NF64-3; Sequence=VSP 024918, VSP 012190; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.||DOMAIN:The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.||SIMILARITY:Contains 1 SP-RING-type zinc finger.||SEQUENCE CAUTION:Sequence=AAH21924.1; Type=Erroneous init

Subcellular localization

Nucleus.

Gene name

zinc finger, MIZ-type containing 2

Protein sequence

MNSMNPMKPALPPAPHGDGSFAYESVPWQQSATQPAGSLS VVTTVWGVGNATQSQVLGNPMGPAGSPSGSSMMPGVAGG SSALTSPQCLGQQAFAEGGANKGYVQQGVYSRGGYPGAP GFTTGYAGGPGGLGLPSHAARPSTDFTQAAAAAAVAAAA ATATATATATVAALQEKQSQELSQYGAMGAGQSFNSQFL QHGGPRGPSVPAGMNPTGIGGVMGPSGLSPLAMNPTRAA GMTPLYAGQRLPQHGYPGPPQAQPLPRQGVKRTYSEVYP GQQYLQGGQYAPSTAQFAPSPGQPPAPSPSYPGHRLPLQ QGMTQSLSVPGPTGLHYKPTEQFNGQGASFNGGSVSYSQ PGLSGPTRSIPGYPSSPLPGNPTPPMTPSSSVPYMSPNQ EVKSPFLPDLKPNLNSLHSSPSGSGPCDELRLTFPVRDG VVLEPFRLQHNLAVSNHVFQLRDSVYKTLIMRPDLELQF KCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHK PLYLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVR SVLQGLLKKRLLPAEHCITKIKRNFSSGTIPGTPGPNGE DGVEQTAIKVSLKCPITFRRIQLPARGHDCRHIQCFDLE SYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGILIYI QNSDYEEITIDPTCSWKPVPVKPDMHIKEEPDGPALKRC RTVSPAHVLMPSVMEMIAALGPGAAPFAPLQPPSVPAPS DYPGQGSSFLGPGTFPESFPPTTPSTPTLAEFTPGPPPI SYQSDIPSSLLTSEKSTACLPSQMAPAGHLDPTHNPGTP GLHTSNLGAPPGPQLHHSNPPPASRQSLGQASLGPTGEL AFSPATGVMGPPSMSGAGEAPEPALDLLPELTNPDELLS YLGPPDLPTNNNDDLLSLFENN

Database cross reference

RefSeq Protein accession:NP_113637
RefSeq Protein gi:54607108

GO:0043596;C:nuclear replication fork;IDA:UniProtKB.

GO-F

GO:0030374;F:ligand-dependent nuclear receptor transcription coactivator activity;IDA:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0045944;P:positive regulation of transcription from RNA polymerase II promoter;IDA:UniProtKB. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr48908

PHOSPHORYLATION

109

Y

PhosphoSitePlus

464939

HTP

N

Regulation_of_Androgen_receptor_activity