Protein basic information
| LiverAtlas Protein ID |
HuLPr49006 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9Y2X9;Q9NY92; |
|
Protein name |
Zinc finger protein 281 |
|
Comment |
FUNCTION:Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes.||SUBCELLULAR LOCATION:Nucleus.||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||SIMILARITY:Belongs to the krueppel C2H2-type zinc-finger protein family.||SIMILARITY:Contains 4 C2H2-type zinc fingers.||SEQUENCE CAUTION:Sequence=CAB70967.1; Type=Erroneous initiation; |
|
Subcellular localization |
Nucleus. |
|
Gene name |
|
|
Protein sequence
|
MKIGSGFLSGGGGTGSSGGSGSGGGGSGGGGGGGSSGRRA EMEPTFPQGMVMFNHRLPPVTSFTRPAGSAAPPPQCVLS SSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSW GFLQSLVSIKQEKPADPEEQQSHHHHHHHHYGGLFAGAE ERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVL LSSSSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIKAKR KPSASSKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSY HLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSR EKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQ YFSRTDRLLKHRRTCGEVIVKGATSAEPGSSNHTNMGNL AVLSQGNTSSSRRKTKSKSIAIENKEQKTGKTNESQISN NINMQSYSVEMPTVSSSGGIIGTGIDELQKRVPKLIFKK GSRKNTDKNYLNFVSPLPDIVGQKSLSGKPSGSLGIVSN NSVETIGLLQSTSGKQGQISSNYDDAMQFSKKRRYLPTA SSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDS SALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDP FNIAEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKASM LQEYSKYLQQAFEKSTNASFTLGHGFQFVSLSSPLHNHT LFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFG SQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAF QSSSQKLTSQKEQKNLESSTGFQIPSQELASQIDPQKDI EPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDH RVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR |
|
Database cross reference |
RefSeq Protein accession:NP_036614
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IDA:UniProtKB. |
|
GO-F |
GO:0010843;F:promoter binding;IDA:UniProtKB. GO:0003700;F:sequence-specific DNA binding transcription factor activity;IDA:UniProtKB. GO:0003704;F:specific RNA polymerase II transcription factor activity;TAS:ProtInc. GO:0016563;F:transcription activator |
|
GO-P |
GO:0000122;P:negative regulation of transcription from RNA polymerase II promoter;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr49006 |
PHOSPHORYLATION |
284 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
395 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
484 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
600 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
785 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
807 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
160 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
203 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
209 |
T |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
783 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
785 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
353 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
479 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
484 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
284 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
395 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49006 |
PHOSPHORYLATION |
807 |
S |
PhosphoSitePlus |
LTP |
N |
|
