HuLPr49060

Uniprot ID

ZN410_HUMAN

Uniprot Acc

Q86VK4;O00153;Q9BQ19;

Protein name

Zinc finger protein 410

Comment

FUNCTION:Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.||SUBUNIT:Interacts with CDKN2A/p14ARF.||SUBCELLULAR LOCATION:Nucleus (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86VK4-1; Sequence=Displayed; Name=2; IsoId=Q86VK4-2; Sequence=VSP 008485, VSP 008486; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; IsoId=Q86VK4-3; Sequence=VSP 008487; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed.||INDUCTION:During fibroblast senescence.||PTM:Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.||SIMILARITY:Contains 5 C2H2-type zinc fingers.

Subcellular localization

Nucleus(Probable).

Gene name

zinc finger protein 410

Protein sequence

MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLS LLPVTEASECSRLMLPDDTTNHSNSSKEVPSSAVLRSLR VNVGPDGEETRAQTVQKSPEFLSTSESSSLLQDLQPSDS TSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSES TDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGEN VHLGSGDGQSKDSGPLPQVEKKLKCTVEGCDRTFVWPAH FKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHN GEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEA QGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSG SRNVHMRKHHLQLGAAGSQEQEQTAEPLMGSSLLEEASV PSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGS PRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERRT

Database cross reference

RefSeq Protein accession:NP_067011
RefSeq Protein gi:10863995

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.