Protein basic information
| LiverAtlas Protein ID |
HuLPr49066 |
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Uniprot ID |
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Uniprot Acc |
Q2M1K9;O94860;Q76N04;Q9NZ13; |
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Protein name |
Zinc finger protein 423 |
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Comment |
FUNCTION:Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.||SUBUNIT:Homodimer (By similarity). Interacts with PARP1 and EBF1 (By similarity). Interacts with SMAD1 and SMAD4.||INTERACTION:P10276:RARA; NbExp=2; IntAct=EBI-950016, EBI-413374; P10826:RARB; NbExp=1; IntAct=EBI-950016, E |
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Subcellular localization |
Nucleus. |
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Gene name |
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Protein sequence
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MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSR ALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESL ADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQM IGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRHE QIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHC HECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTS SLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQ TEELEKHVLTRHPQLSEKADLQCIHCPEVFVDENTLLAH IHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSN HSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPL RGQKKMRDDGQGWTKVVYSCPYCSKRDFNSLAVLEIHLK TIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKNHAY PVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNA NPSDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSAK LESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKE NHKNIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLSASAN SISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQAC PQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSS VDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVK HSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAH KCIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAII LLEKHLREKHCVFDAATENGTANGVPPMATKKAEPADLQ GMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTME VLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSR TFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTE HKVTHSKSLDTGTCRICKMPLQSE |
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Database cross reference |
RefSeq Protein accession:NP_055884
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IDA:UniProtKB. |
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GO-F |
GO:0016563;F:transcription activator activity;IDA:UniProtKB. GO:0016564;F:transcription repressor activity;IDA:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0045892;P:negative regulation of transcription, DNA-dependent;IDA:UniProtKB. GO:0007399;P:nervous system development;IEA:UniProtKB-KW. GO:0045893;P:positive regulation of transcription, DNA-dependen |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr49066 |
PHOSPHORYLATION |
604 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr49066 |
PHOSPHORYLATION |
614 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr49066 |
PHOSPHORYLATION |
1054 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr49066 |
PHOSPHORYLATION |
382 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr49066 |
PHOSPHORYLATION |
386 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49066 |
PHOSPHORYLATION |
387 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr49066 |
PHOSPHORYLATION |
383 |
T |
PhosphoSitePlus |
LTP |
N |
|
